Insulin-Like Growth Factor-1 Signaling in Engineered Articular Cartilage

[Academic_Project Reports]

Insulin-Like Growth Factor-1 Signaling in Engineered Articular Cartilage


Abstract: Articular cartilage can easily become damaged or diseased and it does not have the ability to heal itself. A tissue engineering approach to regenerate cartilage is to integrate chondrocytes, the primary cell in cartilage, with biomaterials and biomolecules. Currently, there is limited knowledge on how all these factors influence the expression of upstream insulin-like growth factor-1 (IGF-1) signaling molecules. In an effort to better understand how IGF-1 and phenotypic, type II collagen, expression can be modified by altering construct properties, chondrocytes were embedded in alginate hydrogels.

Author:Yoon, Diana Meeae

Source:http://hdl.handle.net/1903/8902